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张竞方

张竞方

副教授,硕士生导师

 

                     研究急性髓系白血病的分子和细胞致病机制并发现新的药物靶点 (To study the molecular and cellular mechanisms of acute myeloid leukemia and to identify novel therapeutic targets)

  • 2008.9 -2015.5  威斯康星大学-麦迪逊分校,博士,癌症生物学
  • 2000.9 -2004.7  兰州大学,学士,生物

起止年月 研究工作单位
2018.3 -至今

北京中医药大学生命科学学院,副教授

2016.1 -2018.3 中国科学院动物研究所干细胞与生殖生物学国家重点实验室,博士后
2015.6 -2015.8 威斯康星大学-麦迪逊分校McArdle癌症研究实验室,博士后
2007.5 -2008.8 哈佛大学Dana Farber癌症研究所,研究助理

主持课题

课题级别 项目类型 课题名称 负责人
国家级 国家自然科学基金青年科学基金项目 利用CRISPR基因敲除文库构建诱发AML的协同作用信号通路网络 张竞方

学术组织

学会名称 担任职务
美国血液学会 成员

学术论文

1. Lu, J.*, Zhao, C.*, Zhao, Y.*, Zhang, J.*, Zhang, Y., Chen, L., Han, Q., Ying, Y., Peng, S., Ai, R., Wang, Y. Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and Genome Editing. Nucleic Acids Research, 2018 Mar 16;46(5):e25. doi: 10.1093/nar/gkx1222 (* equally contributed to this study) (IF=10.2)

2. Zhao, C.*, Zhang, Y.*, Zhao, Y., Zhao, Y., Ai, R., Zhang, J., Wang, Y. Multiple chemical inducible Tal effectors for genome editing and transcription activation. ACS Chemical Biology, 2018 Mar 16;13(3):609-617 (* equally contributed to this study) (IF=5.1)

3. Zhang, J.*, Kong, G.*, Rajagopalan, A., Lu L., Song, J., Hussaini, M., Zhang, X., Ranheim, E. A., Liu, Y., Wang, J., Gao, X., Chang, Y.-I., Johnson, K., Zhou, Y., Yang, D., Bhatnagar, B., Lucas, D. M., Bresnick, E., Zhong, X., Padron, E., Zhang, J. p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. Blood. 2017 Jan 19;129(3):358-370. (* equally contributed to this study) (IF=11.8)

4. Zhang, J., Ranheim, E. A., Du, J., Liu, Y., Wang, J., Kong, G., Zhang, J. Deficiency of b common receptor moderately attenuates the progression of myeloproliferative neoplasm in NrasG12D/+ mice. J. Biol. Chem. 2015 Jul 31;290(31):19093-103. (IF=4.3)

5. Chang, Y.-I., Damnernsawad, A., Allen, L. K., Yang, D., Ranheim, E. A., Young, K. H., Zhang, J., Kong, G., Wang, J., Liu, Y., Fu, H.-Y., Yang, C.-S., Guo, J., Song, H., and Zhang, J.  Evaluation of Allelic Strength of Human TET2 Mutations and Cooperation between Tet2 Knockdown and Oncogenic Nras Mutation. Br. J. Haematol., 2014 Aug;166(3):461-5. (IF=5.4)

6. Kong, G., Wunderlich, M., Yang, D., Ranheim, E. A., Young, K. H., Wang, J., Chang, Y.-I., Du, J., Liu, Y., Tey, S. R., Zhang, X., Juckett, M., Mattison, R., Damnernsawad, A., Zhang, J., Mulloy, J. C., and Zhang, J. Combined MEK and JAK Inhibition Abrogates Murine Myeloproliferative Neoplasm. J. Clin. Invest., 2014 Jun;124(6):2762-73. (IF=12.6)

7. Wang, J., Kong, G., Liu, Y., Du, J., Chang, Y.-I., Tey, S. R., Zhang, X., Ranheim, E. A., Saba-El-Leil, M. K., Meloche, S., Damnernsawad, A., Zhang, J., and Zhang, J. NrasG12D/+ Promotes Leukemogenesis by Aberrantly Regulating Hematopoietic Stem Cell Functions. Blood, 2013 Jun 27;121(26):5203-7. (IF=11.8)

8. Du, J., Liu, Y., Meline, B., Kong, G., Tan, L. X., Lo, J. C., Wang, J., Ranheim, E., Zhang, L., Chang, Y. I., Ryu, M.J., Zhang, J., and Zhang, J. Loss of CD44 Attenuates Aberrant GM-CSF Signaling in Kras G12D Hematopoietic Progenitor/Precursor Cells and Prolongs the Survival of Diseased  Animals. Leukemia, 2013 Mar;27(3):754-7. (IF=12.1)

9. Du, J., Wang, J., Kong, G., Jiang, J., Zhang, J.Liu, Y., Tong, W., Zhang, J. Signaling profiling at single-cell level identifies a distinct signaling signature in murine hematopoietic stem cells. Stem Cells, 2012 Jul;30(7):1447-54. (IF=5.9)

10. Ding, Z., Wu, C. J., Jaskelioff, M., Ivanova, E., Kost-Alimova, M., Protopopov, A., Chu, G. C., Wang, G., Lu, X., Labrot, E. S., Hu, J., Wang, W., Xiao, Y., Zhang, H., Zhang, J., Zhang, J.Gan, B., Perry, S. R., Jiang, S., Li, L., Horner, J. W., Wang, Y. A., Chin, L., DePinho, R. A. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell, 2012 Mar 2;148(5):896-907. (IF=28.7)

11. Ding, Z., Wu, C. J., Chu, G. C., Xiao, Y., Ho, D., Zhang, J.Perry, S. R., Labrot, E. S., Wu, X., Lis, R., Hoshida, Y., Hiller, D., Hu, B., Jiang, S., Zheng, H.,Stegh, A.H., Scott, K. L., Signoretti, S., Bardeesy, N., Wang, Y. A., Hill, D. E., Golub, T. R., Stampfer, M. J., Wong, W. H., Loda, M., Mucci, L., Chin, L., DePinho, R. A. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature, 2011 Feb 10;470(7333):269-73. (IF=38.1)