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卢涛

卢涛

特聘教授,博士生导师、硕士生导师

邮箱:taolu@bucm.edu.cn

         1、衰老和老年痴呆症的机理 (mechanistic study for human aging and dementia)

         2、能量医学及机理研究 (energy medicine)

  •    1989年毕业于上海复旦大学应用化学专业
  •    1997年作为中科院和德国马普所的联合培养博士取得物理化学专业的博士学位

 

    1997-2001年期间在哥伦比亚大学从事电生理和离子通道方面的博士后研究

    2001-2004年在哈佛医学院儿童医院从事神经科学的博士后研究

    2005-2016年先后在哈佛医学院神经科学系,病理系,遗传系任教职,做为研究科学家从事衰老和老年痴呆症的机理研究

主要奖励

  • 1997年 Academia Sinica President Award
  • 2000年 America Heart Association postdoctoral fellowship
  • 2002年 NIH Molecular Biology of Neurodegeneration Training Grant

 

学术论文

美国生物物理学会会员

美国神经生物学会会员

 

部分代表文章

1、Kang C, Xu Q, Martin T, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ.  The DNA Damage Response activates inflammation and senescence by protecting GATA4 from selective autophagy. Science. (2015) Sep 25; 349(6255).

2、Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA.  REST and stress resistance in ageing and Alzheimer’s disease. Nature. (2014) online Mar 19.

3、Sun F, Park K, Berlin S, Wang DQ, Lu T, Chen G, Teung C, Feng GP, Yankner BA, He ZG. Sustained axon regeneration induced by a synergy of PTEN and SOCS3 deletion. Nature. (2011), online Nov 6.

4、Yankner, BA, Lu T.  Amyloid β-protein toxicity and the pathogenesis of Alzheimer Disease. J. Bio.Chem (2009), Feb 20, 284(8), 4755-4759.

5、Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline, Nature. (2010), Mar 25; 464 (7288):529-35.  

6、Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, and Yankner BA.  Gene regulation and DNA damage in the ageing human brain. Nature. (2004), Jun 24; 429(6994):883-91.  

7、Lu T, Ting, A, Jan, LY, Schultz, PG, and Yang, J.  Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter. Nature Neuroscience. (2001), 4(3), 1-8.

8、Loerch, PM*., Lu,T*., Darkin, KA., Vann, JM., Issacs, A., Geula, C., Wang, J., Pan, Y., Gabuzda, DH., Li, C., Prolla, TA., Yankner, BA.  Evolution of the aging brain transcriptome and synaptic regulation. PLoS One , (2008), 3(10): e3329. * equally contributed.

9、Yankner, BA., Lu, T.,  Loerch, PM..  The Aging Brain.  Annu Rev Pathol  (2008), Vol. 3 Pg. 41-66

10、Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T., MacDonald, M., Yankner, BA., and Yuan, J. Regulation of intracellular accumulation of mutant huntington by beclin 1. J. Biol. Chem.  (2006), May 19:281(20), 14474-14485.

11、Lu, T., Wu, L., Xiao, J., Yang, J.  Permeant ion-dependent changes in single-channel gating of Kir2.1 inward rectifier potassium channels.  J. Gen. Physiol.  (2001), 118(5), 509-521.

12、Lu, T., Nguyen, B., Zhang, X. M., Yang, J. Architecture of a K+ channel inner pore revealed by stoichiometic covalent modification.  Neuron. (1999), 22, 571-580.

13、Lu, T., Zhu, Y. G., Yang, J. Cytoplasmic amino and carboxyl domains form a wide intracellular vestibule in an inwardly rectifying potassium channel.  Proc. Natl. Acad. Sci. USA. (1999), 96, 9926-9931.

14、Lu, T., Rothe, U., Maik, L., Schaffer, H., Hufnagel, P., Bakowsky, U.  Investigation of the orientation of purple membrane sheets in Langmuir-Blodgett films by a Quartz Crystal Microbalance IUBMB Life. (1999), 48, 1-8.

15、Lu, T., Li, B. F., Jiang, L., Rothe, U., Bakowsky, U. The pH and temperature inversion of differential photocurrent.  J. Chem. Soc. Faraday. Transaction.  (1998). 94(1), 79-81.